Despite the availability of a myriad of Information and Communication Technologies (ICT) based tools and methodologies for supporting governance and the formulation of policies, including modelling expected impacts, these have proved to be unable to cope with the dire challenges of the contemporary society. In this chapter we present the results of the analysis of a set of promising cases researched in order to understand the possible impact of what we define ‘Policy Making 2.0’, which refers to ‘a set of methodologies and technological solutions aimed at enabling better, timely and participative policy-making’. Based on the analysis of these cases we suggest a bouquet of (mostly ICT-related) practical and research recommendations that are relevant to researchers, practitioners and policy makers in order to guide the introduction and implementation of Policy Making 2.0 initiatives. We argue that this ‘decalogue’ of Policy Making 2.0 could be an operational checklist for future research and policy to further explore the potential of ICT tools for governance and policy modelling, so to make next generation policy making more ‘intelligent’ and hopefully able to solve or anticipate the societal challenges we are (and will be) confronted today and in the future.